Research

MD THESIS: THE GENETICS OF COELIAC DISEASE (AWARDED 31/10/2003)

 

Published Articles

 

Moodie S, Gould SJ. Coexistent Coeliac and Crohn's Disease, 2 case histories.CME Journal Gastroenterology, Hepatology and Nutrition1999;2:2;41-44.

Moodie SJ, Maxwell JD. Hereditary Haemochromatosis - developments in pathophysiology, diagnosis and management.CME Gastroenterology2001;4(1):21-24

Moodie S, Ciclitira P. Coeliac Disease: genetic factors and antigen presentation.Acta Endoscopica2001;Vol31;No3; 255-264

King AL, Fraser JS, Moodie SJ, Curtis D, Dearlove AM, Ellis HJ, Rosen-Bronsen S, Ciclitira P. Coeliac disease: follow-up linkage study provides further support for existence of a susceptibility locus on chromosome 11p11.Annals Human Genet.2001(July);Vol65; 377-386.

Moodie SJ, Ang L, Stenner J, Finlayson C, Khotari A, Levin GE and Maxwell JD. Testing for haemochromatosis in a liver clinic population: relationship between ethnic origin, HFE gene mutations, liver histology and serum iron markers.
Eur J Gastroenterol Hepatol.2002 Mar;14(3):223-9.

Moodie SJ, Norman PJ, King AL, Fraser JS, Curtis D, Ellis HJ, Vaughan R, Ciclitira PJ. Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters.
Eur J Immunogenet.2002 Aug;29(4):287-91.

King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ellis, Ciclitira PJ. CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease inUKfamilies.J Med Genet2002;39(1):51-4

Moodie Simon, Ciclitira Paul.Recent developments in coeliac disease.Curr Opin Gastroenterol2002,18:182-186

Poullis A, Zar S, Sundaram K, Moodie S, Risley P, Theodossi A, Mendall MA A new, highly sensitive assay for C-reactive protein can aid the differentiation of inflammatory bowel disorders from constipation- and diarrhoea-predominant functional bowel disorders.Eur J Gastroenterol Hepatol. 2002 Apr;14(4):409-12.

Karell K*, Louka AS*, Moodie SJ*, Ascher H, Clot F, Greco L, Ciclitira PJ, Sollid LM, Partanen J. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the european genetics cluster on celiac disease.
Human Immunology2003 Apr;64(4):469-77. (*these authors contributed equally)

Louka AS, Moodie SJ, Karell K, Bolognesi E, Ascher H, Greco L, Momigliano-Richiardi P, Partanen J, Ciclitira PJ, Sollid LM A collaborative European search for non-DQA1*05-DQB1*02 celiac disease loci on HLA-DR3 haplotypes: analysis of transmission from homozygous parents.Hum Immunol2003 Mar;64(3):350-8

Moodie SJ, Maxwell JD. The phenotypic expression of the HFE gene mutation (C282Y) among the hospitalised population. GUT2001;Jul;49(1):156 [Letter]

Poullis A, Moodie SJ, Maxwell JD. Clinical haemochromatosis in HFE mutation carriers.
Lancet.2002 Aug 3;360(9330):411-2; author reply 413-4.Fraser JS, Engel W, Ellis HJ, Moodie SJ, Pollock EL, Wieser H, Ciclitira PJ. Coeliac disease: in vivo toxicity of the putative immunodominant epitope.Gut. 2003 Dec;52(12):1698-702.

Fraser JS, King AL, Ellis HJ, Moodie SJ, Bjarnason I, Swift J, Ciclitira PJ. An algorithm for the family screening of coeliac disease.World J Gastroenterol.2006 Dec 28;12(48):7805-9.Holopainen P, Naluai AT,Moodie S, Percopo S, Coto I, Clot F, Ascher H, Sollid L, Ciclitira P, Greco L, Clerget-Darpoux F, Partanen J; Members of the European Genetics Cluster on Coeliac Disease. Candidate region 2q33 in European families with coeliac disease.Tissue Antigens.2004 Mar;63(3):212-22.

King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ciclitira PJ. Coeliac disease: Investigation of proposed causal variants in the CTLA4 gene region.Eur J Immunogenet2003; 30(6): 427-32

Poullis A, Moodie SJ, Ang L, Finlayson CJ, Levin GE, Maxwell JD. Routine transferrin saturation measurement in liver clinic patients increases detection of hereditary haemochromatosis.Ann Clin Biochem.2003 Sep;40(Pt 5):521-7.

Ciclitira PJ, Moodie SJ.Transition of care between paediatric and adult gastroenterology. Coeliac disease.Best Pract Res Clin Gastroenterol. 2003 Apr;17(2):181-95.

Lee LY, Abbott L, Mahlangu B, Moodie SJ, Anderson S. The management of cyclic vomiting syndrome: a systematic review.Eur J Gastroenterol Hepatol. 2012 May 24. [Epub ahead of print]

Lee LY, Abbott L,Moodie S, Anderson S. Cyclic vomiting syndrome in 28 patients: features, demographics and outcomes.Eur J Gastroenterol Hepatol. 2012 May 20. [Epub ahead of print]

 

Book Chapters

 

Moodie SJ, Ciclitira P. The genetics of coeliac disease. In Coeliac disease (provisional title)[To be published by: Verlag Wissenschaftliche Scripten, Zwickau (tubingen, Germany)].

 

Oral Presentations

 

Moodie S, Stenner J, Levin GE, Ang L, Maxwell JD. Which is the best serum iron marker to measure in patients with liver disease as an initial investigation to detect genetic haemochromatosis? Winning Poster and oral presentation, regional BSG conference June 2000.

Moodie S. Haemochromatosis: an update. Oral presentation, St George’s Annual Gastroenterology teaching day, Feb. 2001.

Moodie S. Colorectal cancer - the national screening programme. Chair, St George’s Annual Gastroenterology teaching day, Feb. 2006

 

Posters and abstracts

 

Moodie S, Ang L, Fischer A, Stenner J, Maxwell JD, Levin GE. The combination of heterozygosity for HFE gene mutations and alcohol abuse increases risk of biochemical iron overload. Poster presentation British Society of Gastroenterology March 2000, abstract in GUT supplement 11;46

Moodie S, Ang L, Stenner J, Fischer A, Murday V, Maxwell JD. The relationship between ethnicity and haemochromatosis gene mutations in an ethnically mixed population in South London. Poster presentation British Society of Gastroenterology March 2000, abstract in GUT supplement 11;46

Moodie S, Ang L, Stenner J,Levin GE, Murday V and Maxwell JD. What is the most cost-effective strategy for identifying C282Y genetic haemochromatosis in patients with abnormal liver function? Poster presentation British Society of Gastroenterology March 2000, abstract in GUT supplement 11;46

Moodie S, Ang L, Stenner J, Fischer A, Murday V, Maxwell JD.The distribution of haemochromatosis gene mutations within a multiracial South London population. J. Hepatol (Suppl 2);Vol 32;2000:133. Poster presentation European Association for the Study of the Liver (EASL) May 2000

Moodie S, Ang L, Stenner J, Levin GE, Maxwell JD. Heterozygosity for HFE gene mutations and alcohol abuse are additive risk factors for biochemical iron overload.. J. Hepatol (Suppl 2);Vol 32;2000:244(Abstract). Poster presentation European Association for the Study of the Liver (EASL) May 2000

Moodie S, Stenner J, Levin GE, Ang L, Maxwell JD. Which is the best serum iron marker to measure in patients with liver disease as an initial investigation to detect genetic haemochromatosis? Gut 2000;47(Suppl III):A164. Poster presentation United European gastroenterology Week (UEGW) Nov 2000

Mahmood A, Moodie SJ, Ang L, Maxwell JD, Levin GE, Finlayson C. Both alcohol abuse and heterozygosity for the C282Y mutation increase risk of hepatic siderosis: the effect is not additive. Poster BASL meeting Southampton July 2000, Abstract published  in Hepatology supplement.

Mahmood A, Moodie S, Ang L, Finlayson C, Levin GE, Maxwell JD. Heterozygosity for the C282Y gene mutation and chronic hepatitis C infection have additive effects on hepatic siderosis. Gut 2000;47(Suppl III):A183. Poster presentation UEGW Nov. 2000

Mahmood A, Moodie S, Ang L, Finlayson C, Levin GE, Maxwell JD. Both alcohol abuse and heterozygosity for the C282Y gene mutation increase risk of hepatic siderosis: the effect is not additive. Gut 2000;47(Suppl III):A169. Poster presentation UEGW Nov. 2000

Moodie SJ, King AL, Yiannakou JY, Fraser JS, Kondeatis E, Vaughan RW, Ciclitira PJ. Coeliac disease: evidence of additional susceptibility when the second haplotype is a DR7 DQ2.1 or a DR3 DQ2.2 in DR3 DQ2.2 positive subjects. GUT 2001;48(suppl 1):A77, Poster presentation BSG annual meeting March 2001

King AL, Fraser JS, Moodie SJ, Curtis D, Dearlove AM, Ellis HJ, Rosen-Bronsen S, Ciclitira PJ. Follow-up linkage study of coeliac disease: further evidence for the existence of a susceptibility locus on chromosome 11p11. GUT 2001;48 (suppl 1):A77, Poster presentation BSG annual meeting March 2001

Moodie SJ, Norman PJ, King AL, Fraser JS, Curtis D, Ellis HJ, Vaughan RW, Ciclitira PJ. Analysis of candidate genes on chromosome 19 in coeliac disease: evidence for no association with common leukocyte Receptor (LRC) profiles. Poster Presentation BSG regional meeting June 2001

Fraser JS, Ellis HJ, King AL, Moodie SJ, Bjarnason I, Swift GL, Ciclitira PJ. An algorithm for family screening of coeliac disease.  Gut Vol(49);Suppl III; November 2001: Abstract 1985: Presented as poster UEGW 2001

King A, Fraser JS, Moodie SJ, Ciclitira PJ. Confirmation of putative susceptibility loci in a directed family linkage study of coeliac disease. Poster, Genes and the Gut one day symposium, RCP July 2000.

Moodie SJ, Norman PJ, King AL, Fraser JS, Curtis D, Ellis HJ, Vaughan RW, Ciclitira PJ. Analysis of candidate genes on chromosome 19 in coeliac disease: no evidence for association with common KIR gene profiles or the ILT6 gene deletion. Gut;Vol49(Suppl III); Nov 2001: Abstract no.1534 (Presented as poster UEGW Oct 2001)

King AL, Fraser JS, Moodie SJ, Curtis D, Reid E, Dearlove AM, Ciclitira PJ. CTLA-4 gene polymorphisms and susceptibility to coeliac disease. J Med Genet 2001; 38; Suppl I: Abstract S67: Poster presentation British society for human genetics, Sep 2001

King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ellis HJ, Ciclitira PJ. CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families. Gut Vol49(Suppl III);Nov 2001:Abstract 1406. Poster presented at the UEGW Oct 2001.

Moodie SJ, Fraser JS, King AL, Kondeatis E, Ellis HJ, Ciclitira PJ. The HLA association of coeliac disease: an investigation of UK patients without the common disease-associated DQ2 genotype. Gut Vol 50; Suppl II, April 2002; A89. Poster presentation BSG March 2002

King AL, Moodie SJ, Fraser JS, Dearlove AM, Curtis PJ, Ciclitira PJ. CTLAQ-4/CD28 susceptibility polymorphisms may be different in coeliac disease to those predisposing to type 1 diabetes and Grave’s disease. Gut Vol 50; Suppl II, April 2002; A90. Poster presentation BSG March 2002

Fraser JS, Engel W, Pollock EL, Moodie SJ, Ellis HJ, Wieser H, Ciclitira PJ. In-vivo toxicity of amino acids 57-75 of alpha-gliadin in coeliac disease. Gut Vol 50; Suppl II, April 2002; A19. Presented at BSG March 2002.

King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ciclitira PJ. Coeliac Disease and the CTLA-4/CD28 Gene Region: Evidence for Association in UK Families. Clin Sci 2002; 101(Suppl 46): M23

Lee L, Abbott L, Burnett J, Anderson S, Moodie S. Cyclic vomiting syndrome in 28 patients : demographics, features and oucomes.Gut Vol 61 Suppl 2July 2012 ; PWE-053.

Lee L, Abbott L, Mahlangu B, Moodie S. The Management of cyclic vomiting syndrome : A systematic review of 1141 cases.Gut Vol 61 Suppl 2 July 2012 ; PWE-053.